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In 1990 study in San Diego, CA the 5 active subjects with allergic rhinitis had a lowered total serum IgE from Day 0 to Day 90 while 4 placebo subjects, (2 with allergic rhinitis, 1 with asthma and 1 with both), had flat or increased IgE levels.4 In a randomized, alternative medicine and herbal remedies double-blind, placebo controlled study of symptoms and medicine serum ige levels in san diego, ca in mid-1991, subjects had allergic rhinitis and/or asthma. serum was drawn herbal and medicine at day 0 and day 30. seven of the 10 active treated subjects had a reduction in total serum ige levels. in 10 placebo treated subjects, 5 had levels of total serum ige that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 statistical medicine analysis of the open-label study as well as the double-blind randomized placebo controlled study have shown a significant effect of vitamin b12 herbal in lowering serum ige concentrations.

in january 1997, 62 subjects who had been the placebos in the 1995 study were invited to receive the vitamin b12. in june 1997, the 62 placebo subjects were sent a questionnaire asking: how would you compare your overall allergy (hay fever) symptoms this spring to the last two springs? 20 people responded, with 15 reporting having had the b12 treatment, and 5 not. 12 of the 15 reported at least a slight improvement in overall allergy symptoms, and 1 of the 5. improvement ratios - 12:3 having received treatment, 1:4 not having received treatment.8 a bioequivalence study showed that a 3000 mcg lozenge delivered medicine an equivalent amount of cyanocobalamin to the blood herbal as a 15 mcg injection.9 from the spring to the summer patients with demonstrated allergic rhinitis received with the cyanocobalamin medicine (or placebo) containing lozenge twice daily for 21 consecutive days. all subjects also received c and b oral multivitamins for 21 days. twice daily subjects maintained a nine-week diary on sneezing, runny nose, nasal congestion, itchy eyes, itchy nose and antihistamine (chlorpheniramine) use. in the post-treatment period, the active group (n=15) recorded on average a greater reduction in symptoms and in antihistamine use than the placebo group (n=9). the results yielded reductions (0.1>p>0.01) in total weekly symptom/rescue medication for the active group compared to the placebo for weeks 2, 6, 8 and 9. the results tend to replicate those of the studies on injectable cyanocobalamin.10

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