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In January 1997, 62 subjects who had been the placebos in the 1995 study were invited to receive the vitamin B12. In June 1997, the 62 placebo subjects were sent a questionnaire asking: How would you compare your overall allergy (hay fever) symptoms herbal medicines this spring to the last two springs? 20 people responded, with 15 reporting having had the b12 treatment, and 5 not. 12 of the 15 reported at least a slight improvement in overall allergy symptoms, and 1 of the 5. improvement ratios - 12:3 having received treatment, 1:4 not having received treatment.8 a bioequivalence study showed that a 3000 mcg lozenge delivered an equivalent amount of cyanocobalamin to the blood as a 15 mcg injection.9 from the spring medicines to the summer patients with demonstrated allergic rhinitis received with the cyanocobalamin (or placebo) containing lozenge twice daily for 21 consecutive days. all subjects also received c and b oral multivitamins for 21 herbal days. twice daily subjects maintained a nine-week diary on sneezing, medicines runny nose, nasal congestion, herbal itchy eyes, itchy nose and antihistamine (chlorpheniramine) use. in the post-treatment period, the active group (n=15) medicines recorded on average a greater reduction in symptoms and in antihistamine use than herbal the placebo group (n=9). the results yielded reductions (0.1>p>0.01) in total weekly medicines symptom/rescue medication for the active group compared to the placebo for weeks 2, 6, 8 and 9. the results tend to replicate those of the studies on injectable cyanocobalamin.10

studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, they are directly metabolized in the liver. when b12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. it is during this first pass in its native form that it is believed to exert its therapeutic effect. clinical research: "the world health organization (who) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which ige-mediated allergy may be involved."1 in 1988, asthma and allergic rhinitis subjects were treated with b12. total ige, specific ige and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. eight of the 9 subjects had reduced ige. 2 in 1989 open label studies at two sites in riverside county, ca in 1989. sixteen of the 17 subjects had lowered ige levels from day 0 to day 30.3

all of the active b12 group reporting showed reduction in severity of symptoms ranging from 31% to 70%, while the placebo controls herbal reported either no change or a worsening of symptoms. wilcoxon-rank of .002 for the end-points of sneezing, nasal congestion and runny nose; and p = .005 for ige reductions. in 1992, the above mentioned data from 1988 on were presented by dr. o''connor to the fda. the fda panel acknowledged the safety of the treatment. the panel seemed to be in agreement that the statistics indicated a significant reduction in ige and that a quantitative drop in symptoms was demonstrated. in 1992, belen anibarro, md, studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. the test was repeated after premedication with 1.5 mg of oral cyanocobalamin. in medicines four of the five patients treated, bronchospasm did not develop in the second metabisulfite challenge.6

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